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Increased myelination plays a central role in white matter neuroplasticity

Authors :
Eric D, Kirby
Tory O, Frizzell
Lukas A, Grajauskas
Xiaowei, Song
Jodie R, Gawryluk
Bimal, Lakhani
Lara, Boyd
Ryan C N, D'Arcy
Source :
NeuroImage. 263:119644
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

White matter (WM) neuroplasticity in the human brain has been tracked non-invasively using advanced magnetic resonance imaging techniques, with increasing evidence for improved axonal transmission efficiency as a central mechanism. The current study is the culmination of a series of studies, which characterized the structure-function relationship of WM transmission efficiency in the cortico-spinal tract (CST) during motor learning. Here, we test the hypothesis that increased transmission efficiency is linked directly to increased myelination using myelin water imaging (MWI). MWI was used to evaluate neuroplasticity-related improvements in the CST. The MWI findings were then compared to diffusion tensor imaging (DTI) results, with the secondary hypothesis that radial diffusivity (RD) would have a stronger relationship than axial diffusivity (AD) if the changes were due to increased myelination. Both MWI and RD data showed the predicted pattern of significant results, strongly supporting that increased myelination plays a central role in WM neuroplasticity.

Subjects

Subjects :
Neurology
Cognitive Neuroscience

Details

ISSN :
10538119
Volume :
263
Database :
OpenAIRE
Journal :
NeuroImage
Accession number :
edsair.doi.dedup.....54ffee12decd5056bfb9eb31e37a5ec8
Full Text :
https://doi.org/10.1016/j.neuroimage.2022.119644