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Efficacy of Low-Dose Chlorthalidone and Hydrochlorothiazide as Assessed by 24-h Ambulatory Blood Pressure Monitoring
- Source :
- Journal of the American College of Cardiology. 67:379-389
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- BackgroundThiazide and thiazide-like diuretic agents are being increasingly used at lower doses. Hydrochlorothiazide (HCTZ) in the 12.5-mg dose remains the most commonly prescribed antihypertensive agent in the United States.ObjectivesThis study compared chlorthalidone, 6.25 mg daily, with HCTZ, 12.5 mg daily, by 24-h ambulatory blood pressure (ABP) monitoring and evaluated efficacy. Because HCTZ has been perceived as a short-acting drug, a third comparison with an extended-release formulation (HCTZ-controlled release [CR]) was added.MethodsThis 12-week comparative, double-blind, outpatient study randomized 54 patients with stage 1 hypertension to receive either chlorthalidone, 6.25 mg, (n = 16); HCTZ 12.5 mg (n = 18); or HCTZ-CR 12.5 mg (n = 20). ABP monitoring was performed at baseline and after 4 and 12 weeks of therapy.ResultsAll 3 treatments significantly (p < 0.01) lowered office BP at weeks 4 and 12 from baseline. At weeks 4 and 12, significant reductions in systolic and diastolic 24-h ambulatory and nighttime BP (p
- Subjects :
- medicine.medical_specialty
hypertension
Ambulatory blood pressure
medicine.drug_class
medicine.medical_treatment
Urology
030204 cardiovascular system & hematology
low-dose diuretic agent
Essential hypertension
03 medical and health sciences
0302 clinical medicine
Hydrochlorothiazide
Internal medicine
medicine
030212 general & internal medicine
Antihypertensive drug
Thiazide
business.industry
medicine.disease
Blood pressure
Endocrinology
Chlorthalidone
thiazide
Diuretic
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....54feb1cadeee4a545e9b9c6d7531f490