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Successful treatment of JMML relapsed after unrelated allogeneic transplant with cytoreduction followed by DLI and interferon-alpha: evidence for a graft-versus-leukemia effect in non-monosomy-7 JMML
- Source :
- Bone marrow transplantation. 33(1)
- Publication Year :
- 2004
-
Abstract
- Relapse is the major cause of treatment failure after allogeneic transplantation of children with juvenile myelomonocytic leukemia (JMML), and the role of post-transplant immunomodulation is poorly understood. We report a 12-month-old child with JMML relapsed after unrelated marrow transplantation who received cytoreduction followed by donor lymphocyte infusion (DLI) with improvement, and after addition of interferon-alpha (IFN) achieved complete donor chimerism. He was weaned from IFN and has maintained complete remission for 19 months. This is the first published report of a patient with non-monosomy-7 JMML responding to post-transplant immunomodulation and suggests a role for DLI plus IFN in these patients.
- Subjects :
- Oncology
medicine.medical_specialty
Allogeneic transplantation
Alpha interferon
Antineoplastic Agents
Graft vs Leukemia Effect
Donor lymphocyte infusion
Disease-Free Survival
Recurrence
Internal medicine
Medicine
Humans
Transplantation, Homologous
Interferon alfa
Bone Marrow Transplantation
Chromosome Aberrations
Transplantation
Transplantation Chimera
Hematology
Juvenile myelomonocytic leukemia
business.industry
Remission Induction
Infant
Interferon-alpha
Leukemia, Myelomonocytic, Chronic
medicine.disease
Leukemia
Treatment Outcome
Lymphocyte Transfusion
Immunology
business
Chromosomes, Human, Pair 7
medicine.drug
Subjects
Details
- ISSN :
- 02683369
- Volume :
- 33
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Bone marrow transplantation
- Accession number :
- edsair.doi.dedup.....54fd1617e731e4a47502dfdaead2c0f2