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Immunization-Induced Anaplasma marginale-Specific T-Lymphocyte Responses Impaired by A. marginale Infection Are Restored after Eliminating Infection with Tetracycline
- Source :
- Clinical and Vaccine Immunology. 21:1369-1375
- Publication Year :
- 2014
- Publisher :
- American Society for Microbiology, 2014.
-
Abstract
- Infection of cattle withAnaplasma marginalefails to prime sustained effector/memory T-cell responses, and high bacterial load may induce antigen-specific CD4 T exhaustion and deletion. We tested the hypothesis that clearance of persistent infection restores the exhausted T-cell response. We show that infection-induced T-cell exhaustion, characterized as loss of antigen-specific proliferation, and gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) production are partially restored in cattle following clearance of persistent infection with tetracycline.
- Subjects :
- Microbiology (medical)
Anaplasmosis
Tetracycline
T-Lymphocytes
Clinical Biochemistry
Immunology
Cattle Diseases
Biology
Microbiology
Interferon-gamma
medicine
Animals
Immunology and Allergy
Interferon gamma
Cell Proliferation
Tumor Necrosis Factor-alpha
Cell growth
Effector
T lymphocyte
medicine.disease
Anti-Bacterial Agents
Anaplasma marginale
Immunization
Cattle
Clinical Immunology
Tumor necrosis factor alpha
medicine.drug
Subjects
Details
- ISSN :
- 1556679X and 15566811
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Clinical and Vaccine Immunology
- Accession number :
- edsair.doi.dedup.....54e9f6bf76577e73560e8d52589ad875