Back to Search
Start Over
Alterations in metabolic pathways in stomach of mice infected with Helicobacter pylori
- Source :
- Microbial Pathogenesis. 109:78-85
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Numerous studies of Helicobacter pylori (H. pylori) have been performed, but few studies have evaluated the effects of H. pylori infections using metabolome analysis, which involves the comprehensive study of low molecular weight metabolites. In this study, the metabolites in the stomach tissue of mice that had been infected with H. pylori SS1 for 1, 3, or 6 months were analyzed, and then evaluations of various metabolic pathways were performed to gain novel understandings of H. pylori infections. As a result, it was found that the glycolytic pathway, the tricarboxylic acid cycle, and the choline pathway tended to be upregulated at 1 month after the H. pylori SS1 infection. The urea cycle tended to be downregulated at 6 months after the infection. High levels of some amino acids were observed in the stomach tissue of the H. pylori SS1-infected mice at 1 month after the infection, whereas low levels of many amino acids were detected at 3 and 6 months after the infection. These results suggest that H. pylori infection causes various metabolic alterations at lesional sites, and these alterations might be linked to the crosstalk between H. pylori and the host leading to transition of disease conditions.
- Subjects :
- 0301 basic medicine
Time Factors
Liquid chromatography/mass spectrometry
Gas chromatography/mass spectrometry
Metabolite
Citric Acid Cycle
Biology
Microbiology
Choline
Helicobacter Infections
03 medical and health sciences
chemistry.chemical_compound
Mice
medicine
Metabolome
Animals
Glycolysis
Amino Acids
Metabolome analysis
chemistry.chemical_classification
Helicobacter pylori
Stomach
bacterial infections and mycoses
biology.organism_classification
Amino acid
Up-Regulation
Mice, Inbred C57BL
Metabolic pathway
Disease Models, Animal
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
chemistry
Gastric Mucosa
Urea cycle
Female
Metabolic Networks and Pathways
Subjects
Details
- Language :
- English
- ISSN :
- 08824010
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Microbial Pathogenesis
- Accession number :
- edsair.doi.dedup.....54e1e2266952e7ba3d8fa0e5131742c5