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5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease
5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease
- Source :
- J Alzheimers Dis
- Publication Year :
- 2019
-
Abstract
- Alzheimer's disease (AD) pathology consists of extracellular deposits of amyloid-β peptides (Aβ) and intracellular neurofibrillary tangles. These pathological alterations are accompanied by a neuroinflammatory response consisting of increased expression of inflammatory mediators. An anti-inflammatory strategy designed to prevent or delay the development of AD would benefit from knowing when neuroinflammation appears in the transgenic models during prodromal disease stages relative to Aβ pathology. We investigated the expression patterns of inflammatory mediators in the brain of 5xFAD mice in comparison to development of Aβ deposition. Expression changes in inflammatory mediators and glial markers are more robust in female mice starting at three months of age, in contrast to males in which there is no clear trend through five months. Female and male 5xFAD mice also displayed an age-dependent increase in cortical Aβ deposition congruent with neuroinflammation. Thus, in the 5xFAD mouse model of AD, administration of an anti-inflammatory agent would be most efficacious when administered before three months of age.
- Subjects :
- 0301 basic medicine
Male
Chemokine
Amyloid
Transgene
Prodromal Symptoms
Inflammation
Mice, Transgenic
Article
03 medical and health sciences
Mice
0302 clinical medicine
Alzheimer Disease
Extracellular
Medicine
Animals
Pathological
Neuroinflammation
Sex Characteristics
Amyloid beta-Peptides
biology
business.industry
General Neuroscience
Prodromal Stage
Neurofibrillary Tangles
General Medicine
Mice, Inbred C57BL
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Immunology
biology.protein
Female
Geriatrics and Gerontology
medicine.symptom
Inflammation Mediators
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 70
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....54de9f76f5323279fe73de019fc7f480