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Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma
- Source :
- Gene. 580:134-143
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Cancer cells contain significant alterations in their epigenomic landscape, which several enzyme families reversibly contribute to. One class of epigenetic modifying enzymes is that of histone deacetylases (HDAC), which are receiving considerable scrutiny clinically as a therapeutic target in many cancers. The underlying rationale is that inhibiting HDACs will reverse dysregulated target gene expression by modulating functional histone (or other) acetylation marks. This perspective will discuss a recent paper by Markozashvili and co-workers which appeared in Gene, which indicates that the mechanisms by which HDAC inhibitors (HDACis) alter the epigenetic landscape include widespread alternative effects beyond simply controlling regional epigenetic marks. HDACs are involved in many processes/diseases, and it is not surprising that HDACis have considerable off-target effects, and thus a major effort is being directed toward identification of inhibitors which are selective for HDAC isoforms often uniquely implicated in various cancers. This Perspective will also discuss some representative work with inhibitors targeting individual HDAC classes or isoforms. At present, it is not really clear that isoform-specific HDACis will avoid non-selective effects on other unrecognized activities of HDACs.
- Subjects :
- 0301 basic medicine
Transcription, Genetic
medicine.drug_class
Abexinostat
Chromosomal translocation
Locus (genetics)
Lymphoma, Mantle-Cell
Biology
Hydroxamic Acids
Translocation, Genetic
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cyclin D1
immune system diseases
Cell Line, Tumor
hemic and lymphatic diseases
Genetics
medicine
Humans
Epigenetics
Promoter Regions, Genetic
Benzofurans
Chromosomes, Human, Pair 14
B-Lymphocytes
Chromosomes, Human, Pair 11
Histone deacetylase inhibitor
General Medicine
Chromatin Assembly and Disassembly
Molecular biology
Chromatin
Gene Expression Regulation, Neoplastic
Histone Deacetylase Inhibitors
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Perspective
Histone deacetylase
Subjects
Details
- ISSN :
- 03781119
- Volume :
- 580
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....54db31dd8678687eb6b16d97b336e9cf