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Prognostic significance of tumor budding in biliary tract cancer
- Source :
- European Journal of Surgical Oncology. 48:160-168
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Tumor budding is a significant prognostic indicator for poor survival of several solid tumors. However, due to the lack of a standard scoring system, its clinical application for biliary tract cancer (BTC) is limited.To identify the prognostic significance of tumor budding in BTC.Tumor budding was associated with poor histologic differentiation, lymphovascular invasion, perineural invasion, lymph node metastasis, positive surgical margin, etc. Tumor budding was a predictor of poor OS in univariate (HR: 4.36; 95% CI 3.15 to 6.02; P 0.001) and multivariate (HR: 2.95; 95% CI 2.28 to 3.80; P 0.001) analysis. Similarly, it was also a predictor of poor DFS in univariate (HR: 3.26; 95% CI 2.12 to 4.99; P 0.001) and multivariate (HR: 3.21; 95% CI 1.90 to 5.40; P 0.001) analysis. In addition, tumor budding was also associated with advanced T-stage, poor histologic differentiation, lymph node metastasis, positive resection margin, lymphatic invasion, vascular invasion, and perineural invasion.Results of our study have shown that tumor budding is a strong predictor of poor survival for BTC. The clinical utility of tumor budding as a prognostic marker for BTC should be considered after developing a standard international consensus based on the current evidence.
- Subjects :
- Oncology
medicine.medical_specialty
Scoring system
Lymphovascular invasion
Perineural invasion
Lymph node metastasis
Cholangiocarcinoma
Tumor budding
Internal medicine
Humans
Medicine
Neoplasm Invasiveness
Neoplasm Staging
Proportional Hazards Models
Biliary tract cancer
business.industry
Carcinoma
General Medicine
Prognosis
Biliary tract carcinoma
Survival Rate
Biliary Tract Neoplasms
Bile Duct Neoplasms
Gallbladder Neoplasms
Surgery
Lymph Nodes
Positive Surgical Margin
business
Subjects
Details
- ISSN :
- 07487983
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- European Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....54d375b0bc86d03d2e1cbd1fcb254548