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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
- Source :
- Nature genetics. 40(5)
- Publication Year :
- 2007
-
Abstract
- To identify risk variants for lung cancer, we conducted a multistage genome-wide association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston, Texas. For replication, we evaluated the ten SNPs most significantly associated with lung cancer in an additional 711 cases and 632 controls from Texas and 2,013 cases and 3,062 controls from the UK. Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets. Combined analysis yielded odds ratios of 1.32 (P < 1 × 10−17) for both SNPs. Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk.
- Subjects :
- Male
Linkage disequilibrium
Lung Neoplasms
Genetic Linkage
Single-nucleotide polymorphism
Nerve Tissue Proteins
Receptors, Nicotinic
Polymorphism, Single Nucleotide
Article
Genetic linkage
Genetics
medicine
Humans
Genetic Predisposition to Disease
Genetic Testing
Lung cancer
Aged
Chromosomes, Human, Pair 15
biology
Genome, Human
CHRNA5
Haplotype
Cancer
Middle Aged
medicine.disease
Lung cancer susceptibility
Cysteine Endopeptidases
Haplotypes
biology.protein
Female
Subjects
Details
- ISSN :
- 15461718
- Volume :
- 40
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.doi.dedup.....54cda7199a2886dbb044a49c65578df9