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Synthesis of base-substituted uridine 5'-phosphonate analogues as potential P2Y2 receptor ligands
- Source :
- Collection Symposium
- Publication Year :
- 2011
- Publisher :
- Academy of Sciences of the Czech Republic. Institute of Organic Chemistry and Biochemsitry, 2011.
-
Abstract
- A series of 5-modified 5’-phosphonate derivatives of UMP has been prepared in 6 steps from uridine. The analogs were evaluated for their affinity at the P2Y2 receptor. Several derivatives showed partial agonistic activity at the P2Y2 receptor.
Details
- Language :
- English
- ISBN :
- 978-80-86241-37-1
- ISBNs :
- 9788086241371
- Database :
- OpenAIRE
- Journal :
- Collection Symposium
- Accession number :
- edsair.doi.dedup.....54c937f27ec3b6ee4dff0e4478bcf8e3