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Ramsay Hunt syndrome: pathophysiology of cochleovestibular symptoms
- Source :
- The Journal of Laryngology & Otology. 116:844-848
- Publication Year :
- 2002
- Publisher :
- Cambridge University Press (CUP), 2002.
-
Abstract
- Ramsay Hunt’s hypothesis that herpes zoster oticus results from reactivation of the varicella zoster virus (VZV) in the geniculate ganglion is supported by the detection of viral genome in archival temporal bones of normals and Ramsay Hunt patients by the polymerase chain reaction. Ramsay Hunt syndrome is characterized by the presence of cochleovestibular symptoms in association with facial paralysis. VZV has also been demonstrated in the spiral and/or vestibular ganglion. Two cases are reported in which cochleovestibular symptoms outweighed the facial nerve symptoms, presumably representing VZV reactivation in the spiral and/or vestibular ganglion. From these observations and the known dormancy of VZV in non-neuronal satellite cells, it is argued that the cochleovestibular symptoms in Ramsay Hunt syndrome may result from VZV transmission across the nerves inside the internal auditory canal and that prompt treatment with an antiviral-corticosteroid combination might be justified in the management of any acute non-hydropic cochleovestibular syndrome.
- Subjects :
- Male
medicine.medical_specialty
Hearing Loss, Sensorineural
Prednisolone
viruses
Facial Paralysis
Herpes Zoster Oticus
Acyclovir
Scarpa's ganglion
medicine.disease_cause
Antiviral Agents
Herpes Zoster
Nystagmus, Pathologic
Humans
Medicine
Cranial nerve disease
Glucocorticoids
integumentary system
business.industry
Ramsay Hunt syndrome
Varicella zoster virus
virus diseases
General Medicine
Anatomy
Middle Aged
medicine.disease
Facial nerve
Dermatology
Facial paralysis
Otorhinolaryngology
Vertigo
Female
Virus Activation
sense organs
Geniculate ganglion
medicine.symptom
business
Subjects
Details
- ISSN :
- 17485460 and 00222151
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- The Journal of Laryngology & Otology
- Accession number :
- edsair.doi.dedup.....54c5822bd1db1ec187e556577209cdb9