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Validation of the Effectiveness of Neutrophil-to-lymphocyte Ratio (NLR) as a Predictive Factor in Patients Undergoing Prostate Biopsy With Prostate Specific Antigen (PSA) Between 4.0 and 10.0 ng/ml
- Source :
- In Vivo
- Publication Year :
- 2021
- Publisher :
- International Institute of Anticancer Research, 2021.
-
Abstract
- Background/aim This study aimed to access the effectiveness of serum neutrophil-to-lymphocyte ratio (NLR) in patients undergoing prostate needle biopsy with a prostate specific antigen (PSA) between 4.0 and 10.0 ng/ml. Patients and methods A total of 633 cases were eligible. We evaluated several factors including age, PSA, PSA-density (PSAD), platelet-to-lymphocyte ratio (PLR) and NLR in the presence or absence of prostate cancer (PCa), retrospectively. We evaluated statistically the associations between each factor and pathological findings or Gleason score. Results A total of 201 were evaluated in this study. Regarding the presence or absence of prostate cancer, there were statistically significant differences in age, PSA levels, PSAD, the PLR and NLR. The mean NLR value of the patients with PCa was significantly lower compared to the entire cohort. Multivariate analysis showed that age, PSAD, and NLR were independent risk factors predicting PCa. Conclusion For patients having a PSA between 4.0 and 10.0 ng/ml, NLR was a predicting factor of PCa prior to prostate needle biopsy and an effective biomarker and useful tool for avoiding unnecessary biopsies.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Multivariate analysis
Prostate biopsy
Neutrophils
Biopsy
Urology
urologic and male genital diseases
General Biochemistry, Genetics and Molecular Biology
Prostate cancer
Predictive Value of Tests
Medicine
Humans
Lymphocytes
Neutrophil to lymphocyte ratio
Pathological
Retrospective Studies
Pharmacology
medicine.diagnostic_test
business.industry
fungi
Prostate
Prostatic Neoplasms
Prostate-Specific Antigen
medicine.disease
Prostate-specific antigen
Cohort
Biomarker (medicine)
business
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- In Vivo
- Accession number :
- edsair.doi.dedup.....54b9b0a70ba78051bca636b61203edca