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Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes

Authors :
Martin Burtscher
Daniela Geiger
Barbara Strasser
Markus Schauer
Dietmar Fuchs
Hannes Gatterer
Source :
PLoS ONE, Vol 11, Iss 4, p e0153617 (2016), PLoS ONE
Publication Year :
2016
Publisher :
Public Library of Science (PLoS), 2016.

Abstract

Exhaustive exercise can cause a transient depression of immune function. Data indicate significant effects of immune activation cascades on the biochemistry of monoamines and amino acids such as tryptophan. Tryptophan can be metabolized through different pathways, a major route being the kynurenine pathway, which is often systemically up-regulated when the immune response is activated. The present study was undertaken to examine the effect of exhaustive aerobic exercise on biomarkers of immune activation and tryptophan metabolism in trained athletes. After a standardized breakfast 2 h prior to exercise, 33 trained athletes (17 women, 16 men) performed an incremental cycle ergometer exercise test at 60 rpm until exhaustion. After a 20 min rest phase, the participants performed a 20 min maximal time-trial on a cycle ergometer (RBM Cyclus 2, Germany). During the test, cyclists were strongly encouraged to choose a maximal pedalling rate that could be maintained for the respective test duration. Serum concentrations of amino acids tryptophan, kynurenine, phenylalanine, and tyrosine were determined by HPLC and immune system biomarker neopterin by ELISA at rest and immediately post exercise. Intense exercise was associated with a strong increase in neopterin concentrations (p

Details

ISSN :
19326203
Volume :
11
Database :
OpenAIRE
Journal :
PLOS ONE
Accession number :
edsair.doi.dedup.....54b117d96d7d695c1cc8548daf33ce2e