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Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 11, p e0225685 (2019)
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- The relationship between the ataxia-telangiectasia mutated (ATM) rs1801516 gene polymorphism and risk of radiation-induced late skin side effects remains a highly debated issue. In the present study, we assessed the role of ATM rs1801516 as risk factor for radiation-induced fibrosis and telangiectasia, using the LENT-SOMA scoring scale in 285 breast cancer patients who received radiotherapy after breast conserving surgery. A systematic review with meta-analysis and trial sequential analysis (TSA) was then conducted to assess reliability of the accumulated evidence in breast cancer patients. In our cohort study, no association was found between ATM rs1801516 and grade ≥ 2 telangiectasia (GA+AA vs GG, HRadjusted: 0.699; 95%CI: 0.273-1.792, P = 0.459) or grade ≥ 2 fibrosis (GA+AA vs GG, HRadjusted: 1.175; 95%CI: 0.641-2.154, P = 0.604). Twelve independent cohorts of breast cancer patients were identified through the systematic review, of which 11 and 9 cohorts focused respectively on the association with radiation-induced fibrosis and radiation-induced telangiectasia. Pooled analyses of 10 (n = 2928 patients) and 12 (n = 2783) cohorts revealed, respectively, no association of ATM rs1801516 with radiation-induced telangiectasia (OR: 1.14; 95%CI: 0.88-1.48, P = 0.316) and a significant correlation with radiation-induced fibrosis (OR: 1.23; 95%CI: 1.00-1.51, P = 0.049), which however did not remain significant after TSA adjustment (TSA-adjusted 95%CI: 0.85-1.78). These results do not support an impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer, nevertheless further large studies are still required for conclusive evidences.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_treatment
Cancer Treatment
Ataxia Telangiectasia Mutated Proteins
Toxicology
Pathology and Laboratory Medicine
Vascular Medicine
Mathematical and Statistical Techniques
0302 clinical medicine
Fibrosis
Breast Tumors
Medicine and Health Sciences
Breast-conserving surgery
Booster Doses
Telangiectasia
Vaccines
Multidisciplinary
Statistics
Metaanalysis
Research Assessment
Infectious Diseases
030220 oncology & carcinogenesis
Meta-analysis
Physical Sciences
Medicine
Female
medicine.symptom
Research Article
Cohort study
Clinical Oncology
medicine.medical_specialty
Genotype
Systematic Reviews
Infectious Disease Control
Science
Radiation Therapy
Breast Neoplasms
Research and Analysis Methods
Polymorphism, Single Nucleotide
Skin Diseases
03 medical and health sciences
Breast cancer
Internal medicine
Breast Cancer
medicine
Humans
Telangiectasis
Vascular Diseases
Statistical Methods
Risk factor
Proportional Hazards Models
Toxicity
business.industry
Cancers and Neoplasms
Biology and Life Sciences
medicine.disease
Radiation therapy
030104 developmental biology
Gamma Rays
Clinical Medicine
business
Mathematics
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....54b06e054f037c26c88c07abacc9beb2