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Acinetobacter baylyi ADP1-naturally competent for synthetic biology
- Source :
- Essays in biochemistry. 65(2)
- Publication Year :
- 2021
-
Abstract
- Acinetobacter baylyi ADP1 is a non-pathogenic soil bacterium known for its metabolic diversity and high natural transformation and recombination efficiency. For these features, A. baylyi ADP1 has been long exploited in studying bacterial genetics and metabolism. The large pool of information generated in the fundamental studies has facilitated the development of a broad range of sophisticated and robust tools for the genome and metabolic engineering of ADP1. This mini-review outlines and describes the recent advances in ADP1 engineering and tool development, exploited in, for example, pathway and enzyme evolution, genome reduction and stabilization, and for the production of native and non-native products in both pure and rationally designed multispecies cultures. The rapidly expanding toolbox together with the unique features of A. baylyi ADP1 provide a strong base for a microbial cell factory excelling in synthetic biology applications where evolution meets rational engineering.
- Subjects :
- Acinetobacter baylyi ADP1
0303 health sciences
Acinetobacter
030306 microbiology
Rational engineering
Computational biology
Biology
Biochemistry
Genome
Bacterial genetics
Genome engineering
Metabolic engineering
03 medical and health sciences
Synthetic biology
Metabolic Engineering
Cell factory
Synthetic Biology
Molecular Biology
030304 developmental biology
Subjects
Details
- ISSN :
- 17441358
- Volume :
- 65
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Essays in biochemistry
- Accession number :
- edsair.doi.dedup.....54a34234f56f5447b63e67a931345580