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Structure and Mechanism of Influenza Proton Channels

Structure and Mechanism of Influenza Proton Channels

Authors :
Junfeng Wang
Jason R. Schnell
James J. Chou
Rafal M. Pielak
Source :
Biophysical Journal. (3):198a-199a
Publisher :
Biophysical Society. Published by Elsevier Inc.

Abstract

pH-activated, proton selective channels are required during viral entry and replication of influenza viruses. We determined the high resolution structures of proton channels from influenza A and B viruses by solution NMR spectroscopy. The channel structures reveal pore features that are important for proton gating and proton relay. Structural details of the anti-influenza drug, rimantadine, bound to the channel suggests an unexpected allosteric mechanism of drug inhibition and drug resistance, which has been verified by thorough functional and mutagenesis experiments.The work is supported by NIH grant AI067438.

Details

Language :
English
ISSN :
00063495
Issue :
3
Database :
OpenAIRE
Journal :
Biophysical Journal
Accession number :
edsair.doi.dedup.....547b6f0cd19883597f70c96e2bff8aac
Full Text :
https://doi.org/10.1016/j.bpj.2009.12.1059