Back to Search
Start Over
Structure and Mechanism of Influenza Proton Channels
Structure and Mechanism of Influenza Proton Channels
- Source :
- Biophysical Journal. (3):198a-199a
- Publisher :
- Biophysical Society. Published by Elsevier Inc.
-
Abstract
- pH-activated, proton selective channels are required during viral entry and replication of influenza viruses. We determined the high resolution structures of proton channels from influenza A and B viruses by solution NMR spectroscopy. The channel structures reveal pore features that are important for proton gating and proton relay. Structural details of the anti-influenza drug, rimantadine, bound to the channel suggests an unexpected allosteric mechanism of drug inhibition and drug resistance, which has been verified by thorough functional and mutagenesis experiments.The work is supported by NIH grant AI067438.
Details
- Language :
- English
- ISSN :
- 00063495
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biophysical Journal
- Accession number :
- edsair.doi.dedup.....547b6f0cd19883597f70c96e2bff8aac
- Full Text :
- https://doi.org/10.1016/j.bpj.2009.12.1059