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The significance of transfusion in the past as a risk for current hepatitis B and hepatitis C infection: a study in endoscopy patients
- Source :
- Transfusion. 45(5)
- Publication Year :
- 2005
-
Abstract
- BACKGROUND: The objective was to determine the contribution of transfusion in the past to the risk of current infection with hepatitis B or C among patients attending a large hospital for endoscopic procedures. STUDY DESIGN AND METHODS : Blood samples had been tested for hepatitis markers by routine methods. Patients completed a comprehensive risk factor questionnaire and results were analyzed using computer software. RESULTS : Twenty-seven percent of the 2120 participants in the study received transfusions in the past. There was no increase in prevalence of hepatitis B among those transfused. Compared with nontransfused participants, recipients of blood before the implementation of hepatitis C virus (HCV) screening in 1990 had a 4.6-fold increased risk of HCV infection, whereas those transfused with screened blood had a 3-fold increased risk. The difference between the odds ratios for patients before and after screening was not significant. CONCLUSIONS: Because screening has almost completely eliminated HCV from the blood supply, our finding of a continuing association of HCV infection with transfusion was unexpected. It implies that there are significant other nosocomial risks for hepatitis C transmission associated with the clinical situations where patients received blood. These should be actively investigated.
- Subjects :
- Adult
Male
medicine.medical_specialty
Hepatitis C virus
Immunology
medicine.disease_cause
Risk Factors
Internal medicine
medicine
Prevalence
Immunology and Allergy
Humans
Blood Transfusion
Risk factor
Medical History Taking
Hepatitis
business.industry
Transmission (medicine)
Endoscopy
Hematology
Odds ratio
Hepatitis C
Hepatitis B
Middle Aged
medicine.disease
Multivariate Analysis
Female
Viral disease
New South Wales
business
Subjects
Details
- ISSN :
- 00411132
- Volume :
- 45
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Transfusion
- Accession number :
- edsair.doi.dedup.....54750ffd69d37331d7bd25b3d92caa5e