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Total synthesis of rapamycin
- Publication Year :
- 2016
-
Abstract
- For over 30 years, rapamycin has generated a sustained and intense interest from the scientific community as a result of its exceptional pharmacological properties and challenging structural features. In addition to its well known therapeutic value as a potent immunosuppressive agent, rapamycin and its derivatives have recently gained prominence for the treatment of a wide variety of other human malignancies. Herein we disclose full details of our extensive investigation into the synthesis of rapamycin that culminated in a new and convergent preparation featuring a macro-etherification/catechol-templating strategy for construction of the macrocyclic core of this natural product.
- Subjects :
- Sirolimus
Biological Products
Natural product
Molecular Structure
Organic Chemistry
Total synthesis
Antineoplastic Agents
General Chemistry
Computational biology
Combinatorial chemistry
Catalysis
chemistry.chemical_compound
chemistry
Cyclization
medicine
Humans
Immunosuppressive Agents
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....54706266323cc943ab83a92c095d5f77