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Genetic Linkage of Attention-Deficit/Hyperactivity Disorder on Chromosome 16p13, in a Region Implicated in Autism
- Source :
- American Journal of Human Genetics
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed behavioral disorder in childhood and likely represents an extreme of normal behavior. ADHD significantly impacts learning in school-age children and leads to impaired functioning throughout the life span. There is strong evidence for a genetic etiology of the disorder, although putative alleles, principally in dopamine-related pathways suggested by candidate-gene studies, have very small effect sizes. We use affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13 (maximum LOD score 4.2; P=.000005), building upon an earlier genomewide scan of this disorder. The region overlaps that highlighted in three genome scans for autism, a disorder in which inattention and hyperactivity are common, and physically maps to a 7-Mb region on 16p13. These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism.
- Subjects :
- Male
Genetic Linkage
Biology
Genetic determinism
03 medical and health sciences
0302 clinical medicine
Genetic linkage
Report
mental disorders
medicine
Genetics
Attention deficit hyperactivity disorder
Humans
0501 psychology and cognitive sciences
Genetics(clinical)
Allele
Autistic Disorder
Genetics (clinical)
05 social sciences
Chromosome
Chromosome Mapping
medicine.disease
Developmental disorder
Attention Deficit Disorder with Hyperactivity
Autism
Female
030217 neurology & neurosurgery
Chromosomes, Human, Pair 16
050104 developmental & child psychology
Psychopathology
Subjects
Details
- ISSN :
- 00029297
- Volume :
- 71
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The American Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....546a66dbb9cdd00b6bbeab48ae0e74d9
- Full Text :
- https://doi.org/10.1086/342732