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Evolution of the Population Structure of Staphylococcus pseudintermedius in France
- Source :
- Frontiers in Microbiology, Frontiers in Microbiology, 2018, 9 (3055), ⟨10.3389/fmicb.2018.03055⟩, Frontiers in Microbiology, Vol 9 (2018)
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; Staphylococcus pseudintermedius is a colonizer as well as an important pathogen of dogs where it is responsible for skin, ear and post-operative infections. The emergence of methicillin-resistant S. pseudintermedius (MRSP) in the early 2000s, which were additionally resistant to most veterinary-licensed antibiotics, drew specific attention to these pathogens due to the limitations created in veterinary therapeutic options. Multiple studies showed that the sequence type (ST)71 was the most frequently identified clone in Europe. A few years ago, several publications have suggested a decline of the ST71 clone and the emergence of the ST258 lineage in Northern Europe. In this study, we show that ST71 is also decreasing over time in France and that the non-ST71 population is highly heterogeneous. Globally, the non-ST71 clones are more susceptible to antibiotics, which might be good news for veterinarians. Two other lineages, ST258 and ST496, seem to be successful in France. These isolates, as well as representatives of the ST71 clone, underwent whole-genome sequence. This study shows that the ST71 and ST496 clusters are highly homogenous while the ST258 cluster is more diverse. Each ST possesses a specific pattern of resistance and virulence genes. The reasons for the apparent and simultaneous success of the ST258 and ST496 clones remain unclear. But the emergence of the ST496 clone will require monitoring given its multi-resistant genotype and threat to canine health.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
ST496
Staphylococcus pseudintermedius
Lineage (genetic)
Population
lcsh:QR1-502
Clone (cell biology)
Drug resistance
Biology
Microbiology
ST258
lcsh:Microbiology
03 medical and health sciences
Genotype
education
Pathogen
Genetics
education.field_of_study
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
030104 developmental biology
dog
Multilocus sequence typing
MRSP
MLST
Subjects
Details
- Language :
- English
- ISSN :
- 1664302X
- Database :
- OpenAIRE
- Journal :
- Frontiers in Microbiology, Frontiers in Microbiology, 2018, 9 (3055), ⟨10.3389/fmicb.2018.03055⟩, Frontiers in Microbiology, Vol 9 (2018)
- Accession number :
- edsair.doi.dedup.....54437c55cd716320a0d1dc05782ac2b9