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Human response to a malaria vaccine candidate antigen
- Source :
- Vaccine. 9:467-469
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- The Plasmodium falciparum heat-shock protein 70 (PFHSP70) has been proposed as a potential candidate antigen for a malaria vaccine. In this study the human immune response to this antigen has been evaluated. Enzyme-linked immunosorbent assays (ELISA) were performed on serum samples collected from individuals during and after malarial infection. Only 70% of falciparum malaria patients responded to this antigen during the natural course of infection and 54% of the recovered cases who had no parasitaemia at the time of blood collection lacked detectable antibody. The non-responders to PFHSP70 exhibited an antibody response to total schizont antigens. There was no correlation between the response against total schizont antigens and PFHSP70 antigen. The non-responsiveness against PFHSP70 was not related to age, sex or regional variations. These qualities are undesirable for a vaccine candidate antigen.
- Subjects :
- Adult
Male
Protozoan Vaccines
Adolescent
Plasmodium falciparum
Antibodies, Protozoan
Antigens, Protozoan
Enzyme-Linked Immunosorbent Assay
Immune system
Antigen
parasitic diseases
medicine
Animals
Humans
Heat-Shock Proteins
General Veterinary
General Immunology and Microbiology
biology
Malaria vaccine
Immunogenicity
Public Health, Environmental and Occupational Health
medicine.disease
biology.organism_classification
Virology
Malaria
Infectious Diseases
Humoral immunity
Immunology
biology.protein
Molecular Medicine
Female
Antibody
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....543b49372a11bedef2c94489a4030f06