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Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes
- Source :
- Fertility and Sterility. 94:2197-2201
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- OBJECTIVE: To evaluate the clinical and endocrine differences between main polycystic ovary syndrome (PCOS) phenotypes. DESIGN: To evaluate clinical and hormone parameters in a large group of consecutive women with PCOS diagnosed according Rotterdam criteria and divided according their phenotype. SETTING: University department of medicine. PATIENT(S): Three hundred eighty-two consecutive women with PCOS and 85 ovulatory controls. INTERVENTION(S): Evaluation of clinical and hormone parameters. MAIN OUTCOME MEASURE(S): Blood levels of gonadotropins, testosterone, sex-hormone-binding globulin, dehydroepiandrosterone sulfate, 17α-hydroxyprogesterone, progesterone, glucose, and insulin, and calculation of the free androgen index and insulin sensitivity. RESULT(S): The severe PCOS phenotype (hyperandrogenism, chronic anovulation, and polycystic ovaries: type I classic PCOS) was the most common phenotype in 53.9% of the patients. The phenotype of 8.9% of patients was characterized by hyperandrogenism and chronic anovulation but normal ovaries (type II classic PCOS). The two phenotypes of classic PCOS had similar clinical and endocrine characteristics, but the patients with polycystic ovaries had a higher luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio. Ovulatory PCOS was relatively common (28.8% of PCOS patients) and presented milder clinical and endocrine alterations than the classic PCOS phenotypes. The normoandrogenic phenotype was relatively uncommon. These patients had a normal body mass index, insulin sensitivity, and free androgen index but showed increased levels of LH and LH/FSH ratio. CONCLUSION(S): Ovulatory PCOS represents the mild form of classic PCOS, but the normoandrogenic phenotype, although part of the spectrum, may represent a different disorder or have a different pathogenetic pathway. Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
- Subjects :
- Adult
PCOS, Lipids, Insulin resistance, Fertility, Androgens, Obesity
medicine.medical_specialty
Settore MED/09 - Medicina Interna
endocrine system diseases
Endocrine System
Settore MED/13 - Endocrinologia
Anovulation
Young Adult
chemistry.chemical_compound
Dehydroepiandrosterone sulfate
Sex Hormone-Binding Globulin
Internal medicine
Prevalence
medicine
Humans
Testosterone
Retrospective Studies
Dehydroepiandrosterone Sulfate
Free androgen index
business.industry
Hyperandrogenism
Obstetrics and Gynecology
Luteinizing Hormone
medicine.disease
Settore MED/40 - Ginecologia E Ostetricia
Polycystic ovary
female genital diseases and pregnancy complications
Phenotype
Endocrinology
Reproductive Medicine
chemistry
Case-Control Studies
Androgens
Female
Follicle Stimulating Hormone
Luteinizing hormone
business
Polycystic Ovary Syndrome
Hormone
Subjects
Details
- ISSN :
- 00150282
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Fertility and Sterility
- Accession number :
- edsair.doi.dedup.....5433bfae67681ec8550a281ebbd20967