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Anti-Centromere Antibody Positivity in a Patient with Generalized Morphea
- Source :
- Case Reports in Dermatology, Case Reports in Dermatology, Vol 10, Iss 3, Pp 226-230 (2018)
- Publication Year :
- 2018
- Publisher :
- S. Karger AG, 2018.
-
Abstract
- We report the case of a 45-year-old female with generalized morphea (GM), who exhibited positivity for the anti-centromere antibody (Ab). She frequently developed multiple sclerotic skin lesions, whose histological findings were compatible with morphea. She demonstrated favorable responses to topical and oral steroids. Cases of GM associated with systemic sclerosis (SSc)-specific Abs (anti-Scl-70 Ab, anti-centromere Ab, and anti-RNA polymerase III Ab) have rarely been reported. The previously reported GM cases involving anti-SSc-specific Abs exhibited some skin manifestations of SSc, such as nailfold capillary changes. However, our case did not show any signs of SSc or limited cutaneous SSc. More cases are needed to clarify whether GM with SSc-specific Abs leads to SSc.
- Subjects :
- Skin manifestations
Pathology
medicine.medical_specialty
biology
integumentary system
business.industry
Single Case
Dermatology
lcsh:RL1-803
medicine.disease
Generalized morphea
Centromere antibody
medicine
biology.protein
lcsh:Dermatology
Systemic sclerosis
Antibody
Skin lesion
business
skin and connective tissue diseases
Generalized scleroderma
Anti-centromere antibody
Morphea
Subjects
Details
- Language :
- English
- ISSN :
- 16626567
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Case Reports in Dermatology
- Accession number :
- edsair.doi.dedup.....5433652d96d03c3c9c9b9cd54ef37ae4