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IL4 receptor polymorphism is associated with increased risk of sudden deafness in Korean population
- Source :
- Life Sciences. 78:664-667
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The interleukin 4 receptor (IL4R) polymorphism Q576R (rs 180275) has been well known to be associated with atopy and other inflammatory diseases. A single nucleotide polymorphism (SNP) A > G transition potentiates the binding specificity of the adjacent tyrosine residue. In this study we investigated the possible relationship between sudden deafness (SD) and IL4R polymorphism Q576R in 97 Korean SD patients and 613 controls using pyrosequencing method. The odds ratio (OR) for SD associated with the G vs. A allele was 2.58 [P < 0.0001, 95% confidence interval (CI) = 1.84-3.60]. We then sub-grouped SD into Tinnitus positive (+) and Tinnitus negative (-). G allele in Tinnitus (+) is significantly associated with the development of Tinnitus (+) [X(2) = 32.02, P < 0.0001, OR (95% CI) = 2.74 (1.91-3.93)] but not with Tinnitus (-). Taken together these results suggest that G allele could be a risk factor for SD.
- Subjects :
- Male
medicine.medical_specialty
Single-nucleotide polymorphism
Biology
General Biochemistry, Genetics and Molecular Biology
Atopy
Risk Factors
Internal medicine
Interleukin-4 receptor
otorhinolaryngologic diseases
medicine
Humans
SNP
General Pharmacology, Toxicology and Pharmaceutics
Allele
Genetics
Polymorphism, Genetic
General Medicine
Odds ratio
Hearing Loss, Sudden
medicine.disease
Confidence interval
Receptors, Interleukin-4
Endocrinology
Female
medicine.symptom
Tinnitus
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....5432fa5a7b42e7fec7944b273edcf202