Back to Search
Start Over
Lipid bilayer-coated curcumin-based mesoporous organosilica nanoparticles for cellular delivery
- Source :
- Microporous and Mesoporous Materials. 225:371-377
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties receive enormous attention for biomedical applications. Here, we describe a novel inorganic-organic hybrid material with a strikingly high organic content of almost 50 wt%. The colloidal periodic mesoporous organosilica (PMO) nanoparticles synthesized in this work consist entirely of curcumin and ethane derivatives serving as constituents that are crosslinked by siloxane bridges, without any added silica. These mesoporous curcumin nanoparticles (MCNs) exhibit very high surface areas (over 1000 m2/g), narrow particle size distribution (around 200 nm) and a strikingly high stability in simulated biological media. Additionally, the MCNs are used as a cargo delivery system in live-cell experiments. A supported lipid bilayer (SLB) efficiently seals the pores and releases Rhodamin B as model cargo in HeLa cells. This novel nanocarrier concept provides a promising platform for the development of controllable and highly biocompatible theranostic systems.<br />Comment: 10 pages, 12 figures
- Subjects :
- FOS: Physical sciences
Nanoparticle
02 engineering and technology
Condensed Matter - Soft Condensed Matter
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
General Materials Science
Physics - Biological Physics
Lipid bilayer
Chemistry
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
0104 chemical sciences
Mesoporous organosilica
Chemical engineering
Biological Physics (physics.bio-ph)
Mechanics of Materials
Siloxane
Drug delivery
Soft Condensed Matter (cond-mat.soft)
Nanocarriers
0210 nano-technology
Hybrid material
Mesoporous material
Subjects
Details
- ISSN :
- 13871811
- Volume :
- 225
- Database :
- OpenAIRE
- Journal :
- Microporous and Mesoporous Materials
- Accession number :
- edsair.doi.dedup.....542b4f198312eb3720613f77352b45f3