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Exercise-induced conduction velocity increment: a marker of impaired peripheral nerve blood flow in diabetic neuropathy
- Source :
- Diabetologia. 35(2)
- Publication Year :
- 1992
-
Abstract
- Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 diabetic subjects with established neuropathy and 16 age-matched normal control subjects, before and after exercise to 80% age/sex predicted maximum heart rate. Fixed sural electrodes were used. Subcutaneous temperature was recorded by a needle thermocouple placed near the sural nerve. Sural sensory conduction velocity increased significantly after exercise in normal subjects (p less than 0.01, mean increase 5.07 m/s) and non-neuropathic diabetic subjects (p less than 0.02, mean increase 3.99 m/s) but not in neuropathic subjects (mean increase 0.99 m/s). Subcutaneous temperature rose significantly in normal subjects (p less than 0.01, mean increase 2.07 degrees C) and non-neuropathic diabetic subjects (p less than 0.001, mean increase 2.52 degrees C) but not in neuropathic subjects (mean increase 0.15 degree C). However, sural sensory conduction velocity increased by 1.2 m.s-1.degree C-1 following direct warming of the limb in six neuropathic subjects which was comparable to that of normal and non-neuropathic subjects (1.49 and 1.48 m.s-1. degree C-1). The impairment of exercise conduction increment in diabetic neuropathy suggests impaired nerve blood flow in diabetic neuropathy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Diabetic neuropathy
Hot Temperature
Endocrinology, Diabetes and Metabolism
Physical Exertion
Neural Conduction
Hemodynamics
Physical exercise
Sural nerve
Nerve conduction velocity
Body Temperature
Diabetic Neuropathies
Sural Nerve
Heart Rate
Reference Values
Internal medicine
Diabetes mellitus
Heart rate
Internal Medicine
medicine
Humans
Diabetic Retinopathy
business.industry
Middle Aged
medicine.disease
Peripheral neuropathy
Endocrinology
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Regional Blood Flow
Cardiology
Female
business
Subjects
Details
- ISSN :
- 0012186X
- Volume :
- 35
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....54294de827118f2e027e89dae7efb16d