Back to Search
Start Over
A multiplex SNP assay for the dissection of human Y-chromosome haplogroup O representing the major paternal lineage in East and Southeast Asia
- Source :
- Journal of Human Genetics, 57(1), 65-69. Nature Publishing Group
- Publication Year :
- 2011
-
Abstract
- The majority of human Y chromosomes in men from East and Southeast Asia, and a considerable proportion of Oceanian men, especially those from Remote Oceania, belong to haplogroup O, characterized by a 5-bp deletion known as M175 (rs2032678). Recent advances in Y-SNP (single-nucleotide polymorphism) discovery have substantially improved the phylogenetic resolution of haplogroup O sublineages. By taking advantage of this recent knowledge, we hereby introduce a sensitive Y-SNP multiplex genotyping assay for the dissection of haplogroup O into its most significant sublineages. The multiplex assay thus provides an efficient way to infer patrilineal biogeographic ancestry in males of Asian/Oceanian patrilineal descent, and is suitable for applications in human population genetics, anthropological, genealogical, as well as forensic studies. Journal of Human Genetics (2012) 57, 65-69; doi: 10.1038/jhg.2011.120; published online 3 November 2011
- Subjects :
- Genetic Markers
Male
Haplogroup L4a
Haplogroup N
Genotyping Techniques
Human Y-chromosome DNA haplogroup
Biology
Haplogroup NO
Polymorphism, Single Nucleotide
Haplogroup
Fathers
Genetics
Humans
Haplogroup D-M15
Genetics (clinical)
Asia, Southeastern
Phylogeny
Electrophoresis, Agar Gel
Chromosomes, Human, Y
Asia, Eastern
Reference Standards
Haplogroup IJ
Genetics, Population
Haplotypes
Haplogroup CT
Subjects
Details
- ISSN :
- 1435232X and 14345161
- Volume :
- 57
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of human genetics
- Accession number :
- edsair.doi.dedup.....54202ee0e2d09e7e5cbb312079e9266e