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The treatment landscape in thyroid cancer: a focus on cabozantinib
- Source :
- Cancer Management and Research
- Publication Year :
- 2015
- Publisher :
- Dove Medical Press, 2015.
-
Abstract
- Although patients with thyroid cancer generally fare well, there is a subset for which this is not necessarily true. Progress in understanding the molecular aberrations in thyroid cancer has led to a change in the management of these cases. Since 2011, four multikinase inhibitors (MKIs) have been approved by the US Food and Drug Administration for thyroid cancer - cabozantinib and vandetanib for medullary thyroid cancer and sorafenib and lenvatinib for differentiated thyroid cancer. This change in the treatment landscape has raised challenges for practitioners who may not be familiar with the use of MKIs or with the treatment and natural history of advanced thyroid cancer in general. This article reviews the epidemiology, molecular drivers, and initial treatment of patients with thyroid cancer and offers practical guidance to assist with the determination of when to appropriately start an MKI. As an example, cabozantinib and its efficacy are discussed in detail. Close monitoring is required for all patients on targeted agents to assess for adverse effects and response to therapy. An approach to managing drug-related adverse events is detailed. Since these drugs are not curative and have not yet proven to prolong overall survival, it is critical to weigh the risks and benefits of treatment at every visit. The potential value of changing to a different agent following failure of an MKI is also addressed.
- Subjects :
- Sorafenib
Oncology
medicine.medical_specialty
Cabozantinib
kinase inhibitor
medicine.medical_treatment
adverse event
Review
Vandetanib
Bioinformatics
chemotherapy
Targeted therapy
chemistry.chemical_compound
Internal medicine
medicine
Adverse effect
Thyroid cancer
business.industry
Medullary thyroid cancer
medicine.disease
targeted therapy
VEGF
chemistry
Lenvatinib
business
RET
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 11791322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Cancer Management and Research
- Accession number :
- edsair.doi.dedup.....541c849ab1da2df9e9d72c433c65c396