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Reciprocal interactions between the GH axis and sleep
- Source :
- Growth Hormone & IGF Research. 14:10-17
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- For more than 30 years, growth hormone (GH) has been observed to be preferentially secreted during deep, slow-wave sleep (SWS). However, the mechanisms that underlie this robust relationship that links anabolic processes in the body with behavioral rest and decreased cerebral metabolism remain to be elucidated. Current evidence indicates that GH secretion during the beginning of sleep appears to be primarily regulated by GH-releasing hormone (GHRH) stimulation occurring during a period of relative somatostatin withdrawal, which also is associated with elevated levels of circulating ghrelin. Apparently, two populations of GHRH neurons need to be simultaneously active to stimulate, in a coordinated fashion, SWS and pituitary GH release. Pharmacological interventions that are capable of increasing the duration and/or the intensity of SWS such as oral administration of gamma-hydroxybutyrate (GHB), also increase the rate of GH release. Because the normal negative feedback exerted by GH on central GHRH is inoperative in patients with GH deficiency, it is possible that the decreased energy levels and fatigue often reported by GH-deficient adults partly reflect an alteration in sleep-wake regulation. Preliminary data from a sleep study of adults with GH deficiency using wrist actigraphy for 6 nights at home and polysomnography in the laboratory indeed show decreased total sleep time and increased sleep fragmentation in GH-deficient patients as compared with normal controls.
- Subjects :
- Sleep Wake Disorders
medicine.medical_specialty
medicine.diagnostic_test
Human Growth Hormone
business.industry
Endocrinology, Diabetes and Metabolism
Polysomnography
medicine.disease
Growth hormone secretion
Growth hormone deficiency
Endocrinology
Somatostatin
Pituitary Gland
Internal medicine
Quality of Life
medicine
Humans
Ghrelin
Sleep study
Wakefulness
Sleep
business
Slow-wave sleep
Hormone
Subjects
Details
- ISSN :
- 10966374
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Growth Hormone & IGF Research
- Accession number :
- edsair.doi.dedup.....54110c491e8644f40b10254db064c382