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Temporally-independent functional modes of spontaneous brain activity
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, 109(8), 3131-3136. National Academy of Sciences
- Publication Year :
- 2012
-
Abstract
- Resting-state functional magnetic resonance imaging has become a powerful tool for the study of functional networks in the brain. Even “at rest,” the brain's different functional networks spontaneously fluctuate in their activity level; each network's spatial extent can therefore be mapped by finding temporal correlations between its different subregions. Current correlation-based approaches measure the average functional connectivity between regions, but this average is less meaningful for regions that are part of multiple networks; one ideally wants a network model that explicitly allows overlap, for example, allowing a region's activity pattern to reflect one network's activity some of the time, and another network's activity at other times. However, even those approaches that do allow overlap have often maximized mutual spatial independence, which may be suboptimal if distinct networks have significant overlap. In this work, we identify functionally distinct networks by virtue of their temporal independence, taking advantage of the additional temporal richness available via improvements in functional magnetic resonance imaging sampling rate. We identify multiple “temporal functional modes,” including several that subdivide the default-mode network (and the regions anticorrelated with it) into several functionally distinct, spatially overlapping, networks, each with its own pattern of correlations and anticorrelations. These functionally distinct modes of spontaneous brain activity are, in general, quite different from resting-state networks previously reported, and may have greater biological interpretability.
- Subjects :
- Adult
Time Factors
Brain activity and meditation
IR-83011
Visual system
Motor Activity
Brain mapping
Gyrus Cinguli
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Cognition
medicine
Humans
0501 psychology and cognitive sciences
Visual Pathways
Independence (probability theory)
Network model
Interpretability
Brain Mapping
Multidisciplinary
Resting state fMRI
medicine.diagnostic_test
business.industry
05 social sciences
Brain
Reproducibility of Results
Pattern recognition
Biological Sciences
Magnetic Resonance Imaging
METIS-292333
Artificial intelligence
Nerve Net
business
Functional magnetic resonance imaging
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, 109(8), 3131-3136. National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....540b5630b18a790360faebbbef7e4ae9