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A Systematically Assembled Signature of Genes to be Deep-Sequenced for Their Associations with the Blood Pressure Response to Exercise
- Source :
- Genes, Genes, Vol 10, Iss 4, p 295 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- Background: Exercise is one of the best nonpharmacologic therapies to treat hypertension. The blood pressure (BP) response to exercise is heritable. Yet, the genetic basis for the antihypertensive effects of exercise remains elusive. Methods: To assemble a prioritized gene signature, we performed a systematic review with a series of Boolean searches in PubMed (including Medline) from earliest coverage. The inclusion criteria were human genes in major BP regulatory pathways reported to be associated with: (1) the BP response to exercise; (2) hypertension in genome-wide association studies (GWAS); (3) the BP response to pharmacotherapy; (4a) physical activity and/or obesity in GWAS; and (4b) BP, physical activity, and/or obesity in non-GWAS. Included GWAS reports disclosed the statistically significant thresholds used for multiple testing. Results: The search yielded 1422 reports. Of these, 57 trials qualified from which we extracted 11 genes under criteria 1, 18 genes under criteria 2, 28 genes under criteria 3, 27 genes under criteria 4a, and 29 genes under criteria 4b. We also included 41 genes identified from our previous work. Conclusions: Deep-sequencing the exons of this systematically assembled signature of genes represents a cost and time efficient approach to investigate the genomic basis for the antihypertensive effects of exercise.
- Subjects :
- 0301 basic medicine
lcsh:QH426-470
Genome-wide association study
Physical exercise
Blood Pressure
Review
030204 cardiovascular system & hematology
Bioinformatics
03 medical and health sciences
0302 clinical medicine
healthy lifestyle
physical exercise
Genetics
Medicine
Humans
Gene
antihypertensive therapy
Exercise
Genetics (clinical)
Antihypertensive Agents
Genetic association
business.industry
High-Throughput Nucleotide Sequencing
Exons
Gene signature
lcsh:Genetics
030104 developmental biology
Blood pressure
Multiple comparisons problem
Hypertension
Human genome
business
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 20734425
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Genes
- Accession number :
- edsair.doi.dedup.....5408a94ad8aa2d79f7e19db2a4a34dd9