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Efficacy and Safety of Short-Term Dual Antiplatelet Therapy in East Asians: A Systematic Review and a Meta-Analysis of Randomized Clinical Trials
- Source :
- Journal of Cardiovascular Pharmacology. 79:264-272
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- The optimal duration of dual antiplatelet therapy (DAPT) for patients implanted with new-generation drug-eluting stents in East Asians is currently still controversial. The purpose of this meta-analysis was to investigate the efficacy and safety of short-term DAPT in patients with those. In this study, randomized controlled trials from PubMed, EMBASE, and Cochrane Library were searched to compare the efficacy and safety of short-term DAPT (6 months or less) with long-term DAPT (12 months or more) in patients implanted with new-generation drug-eluting stents in East Asian from inception to September 2020. The primary efficacy outcome was all-cause death, the primary safety outcome was major bleeding, and the secondary outcomes included cardiovascular death, myocardial infarction, definite or possible stent thrombosis, and stroke. A total of 6 randomized controlled trials with 15,688 patients met inclusion criteria; there were no significant differences in the incidence of all-cause death [risk ratio (RR), 1.03; 0.76-1.39; P = 0.856)], cardiovascular death (RR, 0.83; 0.55-1.24; P = 0.361), myocardial infarction (RR, 0.97; 0.72-1.31; P = 0.853), definite or possible stent thrombosis (RR, 1.52; 0.83-2.78; P = 0.170), and stroke (RR, 0.90; 0.61-1.31; P = 0.574) between short-term and long-term DAPTs. However, there was a significant difference in the risk of major bleeding (RR, 0.64; 0.49-0.85; P = 0.002) between the 2 groups. Compared with long-term DAPT, the short-term DAPT can reduce the risk of major bleeding without increasing the risk of death or ischemia for East Asians (Registered by PROSPERO, CRD42020213266).
- Subjects :
- medicine.medical_specialty
animal structures
Myocardial Infarction
Hemorrhage
Cochrane Library
law.invention
Percutaneous Coronary Intervention
Asian People
Randomized controlled trial
law
Internal medicine
Humans
Medicine
In patient
Myocardial infarction
Stroke
Randomized Controlled Trials as Topic
Pharmacology
business.industry
Incidence (epidemiology)
Thrombosis
medicine.disease
Treatment Outcome
Meta-analysis
Drug Therapy, Combination
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
Major bleeding
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Pharmacology
- Accession number :
- edsair.doi.dedup.....53ff1758dfb5c009791c610edb6c132f