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Wolfberry enhanced the abundance of Akkermansia muciniphila by <scp>YAP1</scp> in mice with acetaminophen‐induced liver injury

Authors :
Yiwei Liu
Yu Xue
Zhiqin Zhang
Jingmin Ji
Caige Li
Kangning Zheng
Junlan Lu
Yuting Gao
Yi Gong
Yuman Zhang
Xinli Shi
Source :
The FASEB Journal. 37
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Drug-induced liver injury (DILI) by acetaminophen (APAP) was one of the most challenging liver diseases. Wolfberry (Lycium barbarum L.), a traditional Chinese medicinal material and food supplement, has a potential effect on increasing the abundance of Akkermansia muciniphila (A. muciniphila) in mice colons. However, the effect and mechanism of wolfberry remain unclear in APAP-induced DILI. In this study, wolfberry promoted the proliferation of activated-A. muciniphila in vitro and in vivo. For the first time, we detected that the activated-A. muciniphila but not the killed-A. muciniphila increased the expression level of Yes-associated protein 1 (YAP1) in the liver and alleviated liver injury in APAP-induced DILI mice. Mechanically, A. muciniphila improved the intestinal mucosal barrier and reduced lipopolysaccharide (LPS) content in the liver, leading to the increased expression level of YAP1. Furthermore, wolfberry increased the A. muciniphila abundance in the colon and YAP1 expression in the liver from APAP-induced DILI mice, which promoted the recovery of APAP-induced liver injury. Meanwhile, wolfberry combination with A. muciniphila synergistically increased AKK abundance and YAP1 expression in the liver. Our research provides an innovative strategy to improve DILI.

Details

ISSN :
15306860 and 08926638
Volume :
37
Database :
OpenAIRE
Journal :
The FASEB Journal
Accession number :
edsair.doi.dedup.....53fea32a31852254808eff07d05d6115
Full Text :
https://doi.org/10.1096/fj.202200945r