Additional file 1 of A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

Additional file 1: Figure S1. Alum-adjuvanted RBD protein vaccine induces a Th2-biased immune response. Figure S2. RNA integrity and basic characteristics of WT and variant RBD mRNA-LNP. Figure S3. Spike-specific IgG and neutralization curves of naïve mice immunized by WT and variant RBD mRNA vaccines. Figure S4. Representative enrichment rate of CD8+ cells in splenocytes of naïve mice immunized by WT and variant RBD mRNA vaccines. Figure S5. Neutralization curves of long-term WT vaccinated mice boosted by WT and variant RBD mRNA vaccines.