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A Review of Natural Products for Prevention of Acute Kidney Injury
- Source :
- Medicina, Medicina, Vol 57, Iss 1266, p 1266 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Background and Objectives: acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products—measured by blood urea nitrogen (BUN) and serum creatinine levels—over the course of hours to weeks. AKI occurs in about 20% of all hospitalized patients and is more common in the elderly. Therefore, it is necessary to prevent the occurrence of AKI, and to detect and treat early, since it is known that a prolonged period of kidney injury increases cardiovascular complications and the risk of death. Despite advances in modern medicine, there are no consistent treatment strategies for preventing the progression to chronic kidney disease. Through many studies, the safety and efficacy of natural products have been proven, and based on this, the time and cost required for new drug development can be reduced. In addition, research results on natural products are highly anticipated in the prevention and treatment of various diseases. In relation to AKI, many papers have reported that many natural products can prevent and treat AKI. Conclusions: in this paper, the results of studies on natural products related to AKI were found and summarized, and the mechanism by which the efficacy of AKI was demonstrated was reviewed. Many natural products show that AKI can be prevented and treated, suggesting that these natural products can help to develop new drugs. In addition, we may be helpful to elucidate additional mechanisms and meta-analysis in future natural product studies.
- Subjects :
- Medicine (General)
Modern medicine
medicine.medical_specialty
antioxidant
natural products
Renal function
Review
urologic and male genital diseases
Blood Urea Nitrogen
chemistry.chemical_compound
R5-920
prevention
Medicine
Humans
Intensive care medicine
Blood urea nitrogen
Aged
Creatinine
Biological Products
business.industry
Mechanism (biology)
urogenital system
Acute kidney injury
General Medicine
medicine.disease
female genital diseases and pregnancy complications
chemistry
Drug development
acute kidney injury
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 16489144 and 1010660X
- Volume :
- 57
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Medicina
- Accession number :
- edsair.doi.dedup.....53e8942a680fec2ae2cec633d300a993