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PCB and OCP accumulation and evidence of hepatic alteration in the Atlantic bluefin tuna, T. thynnus, from the Mediterranean Sea
- Publication Year :
- 2016
- Publisher :
- Elsevier Ltd, 2016.
-
Abstract
- Persistent organic pollutants (POPs) are known to act as “obesogens”, being fat-soluble and affecting lipid metabolism. The Atlantic bluefin tuna, Thunnus thynnus, are top pelagic predators prone to bioaccumulate and biomagnify environmental contaminants. This study aimed at evaluating POPs-induced ectopic lipid accumulation in liver of adult tuna from the Mediterranean Sea. PCBs and organochlorine pesticides were measured in tuna liver, and marked morphological changes observed, namely poorly compacted tissues, intense vacuolization, erythrocyte infiltration and presence of melanomacrophages. The expression of perilipin, a lipid-droplet marker, positively correlated with the gene expression of PPARγ, a master regulator of adipogenesis, and its heterodimeric partner, RXRα. Changes in metabolites involved in fatty acid biosynthesis and ketogenesis were also observed. Although male bluefin tuna appeared to be more sensitive than females to the adverse effects of environmental obesogens, the alterations observed in tuna liver of both sexes suggest a potential onset of hepatic steatosis.
- Subjects :
- 0301 basic medicine
Male
Biomagnification, Fish, Lipid metabolism, Liver, Pelagic, POPs, Thunnus thynnus
Zoology
010501 environmental sciences
Aquatic Science
Biology
Oceanography
01 natural sciences
pops
03 medical and health sciences
Ketogenesis
lipid metabolism
medicine
Hydrocarbons, Chlorinated
Mediterranean Sea
Animals
Pesticides
0105 earth and related environmental sciences
fish
Ecology
Tuna
food and beverages
Pelagic zone
Lipid metabolism
General Medicine
pelagic
medicine.disease
biology.organism_classification
Pollution
Polychlorinated Biphenyls
030104 developmental biology
biomagnification
Liver
thunnus thynnus
Bioaccumulation
liver
Perilipin
Female
Steatosis
human activities
Thunnus
Water Pollutants, Chemical
Environmental Monitoring
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....53e2510c67c1fe2ddfbde636e53a513a