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Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division
- Source :
- Journal of Cell Biology, Journal of Cell Biology, Rockefeller University Press, 2016, 212 (1), pp.39-49. ⟨10.1083/jcb.201510063⟩, The Journal of Cell Biology
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- In asymmetrically dividing C. elegans embryos, the core cortical PAR proteins are required to retain septin and anillin at the anterior cortex away from the contractile ring and to promote normal F-actin levels at the contractile ring and successful cytokinesis.<br />Cytokinesis, the physical division of one cell into two, is thought to be fundamentally similar in most animal cell divisions and driven by the constriction of a contractile ring positioned and controlled solely by the mitotic spindle. During asymmetric cell divisions, the core polarity machinery (partitioning defective [PAR] proteins) controls the unequal inheritance of key cell fate determinants. Here, we show that in asymmetrically dividing Caenorhabditis elegans embryos, the cortical PAR proteins (including the small guanosine triphosphatase CDC-42) have an active role in regulating recruitment of a critical component of the contractile ring, filamentous actin (F-actin). We found that the cortical PAR proteins are required for the retention of anillin and septin in the anterior pole, which are cytokinesis proteins that our genetic data suggest act as inhibitors of F-actin at the contractile ring. Collectively, our results suggest that the cortical PAR proteins coordinate the establishment of cell polarity with the physical process of cytokinesis during asymmetric cell division to ensure the fidelity of daughter cell formation.
- Subjects :
- 0301 basic medicine
Cell division
Cell Polarity
macromolecular substances
Cell Biology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Cell cycle
Cell fate determination
Biology
Septin
Cell biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Report
Cell polarity
Asymmetric cell division
Animals
Cleavage furrow
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Research Articles
030217 neurology & neurosurgery
Cytokinesis
Subjects
Details
- Language :
- English
- ISSN :
- 00219525 and 15408140
- Database :
- OpenAIRE
- Journal :
- Journal of Cell Biology, Journal of Cell Biology, Rockefeller University Press, 2016, 212 (1), pp.39-49. ⟨10.1083/jcb.201510063⟩, The Journal of Cell Biology
- Accession number :
- edsair.doi.dedup.....53e2412bc928bf17e1d9e28365d4f957