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Ambient carbon monoxide exposure and elevated risk of mortality in the glioblastoma patients: A double‐cohort retrospective observational study
- Source :
- Cancer Medicine
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- An increasing number of studies indicate air pollutants infiltrate into the brain. We aimed to find the association of cumulative air pollution exposure in the main body of primary brain tumor: glioblastoma (GBM). In this double‐cohort, retrospective analysis study with a protocol, we compared the health effect of air pollution on the GBM patients from the SEER (Surveillance, Epidemiology, and End Results Program) in 27 U.S. counties from 10 states and GBM patients of Severance cohort of Korea. From 2000 to 2015, 10621 GBM patients of the SEER were individually evaluated for the cumulative average exposure for each pollutant, and 9444 (88.9%) mortality events were reported. From 2011 to 2018, 398 GBM patients of the Severance with the same protocol showed 259 (65.1%) mortality events. The multi‐pollutant models show that the association level of risk with CO is increased in the SEER (HR 1.252; 95% CI 1.141‐1.373) with an increasing linear trend of relative death rate in the spline curve. The Severance GBM data showed such a statistically significant result of the health impact of CO on GBM patients. The overall survival gain of the less exposure group against CO was 2 and 3 months in the two cohorts. Perioperative exposure to CO may increase the risk of shorter survival of GBM patients of the SEER and the Severance cohort.<br />This retrospective observational study found that chronic exposure to ambient level of carbon monoxide is associated with a shorter survival of glioblastoma patients (2‐3 months). Such association was validated in the cohorts of the United states (N=10621, HR 1.252, 95% CI 1.141‐1.373) and Korea (N=398, HR 2.874, 95% CI 1.040‐7.944).
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Time Factors
Brain tumor
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Epidemiology
Republic of Korea
medicine
Risk of mortality
Humans
Radiology, Nuclear Medicine and imaging
Original Research
Aged
Retrospective Studies
Air Pollutants
Carbon Monoxide
Inhalation Exposure
business.industry
Brain Neoplasms
glioblastoma
Clinical Cancer Research
Retrospective cohort study
Perioperative
Middle Aged
medicine.disease
Prognosis
mortality
United States
030104 developmental biology
Health effect
030220 oncology & carcinogenesis
Cohort
Female
ambient air pollution
business
Glioblastoma
SEER Program
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 9
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....53ced0ac5fefbb9ed160702757461697