Back to Search
Start Over
New prognostic markers, determined using gene expression analyses, reveal two distinct subtypes of chronic myelomonocytic leukaemia patients
New prognostic markers, determined using gene expression analyses, reveal two distinct subtypes of chronic myelomonocytic leukaemia patients
- Source :
- British Journal of Haematology. 157:347-356
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Summary Chronic myelomonocytic leukaemia (CMML) is a heterogeneous haematopoietic disorder characterized by myeloproliferative or myelodysplastic features. At present, the pathogenesis of this malignancy is not completely understood. In this study, we sought to analyse gene expression profiles of CMML in order to characterize new molecular outcome predictors. A learning set of 32 untreated CMML patients at diagnosis was available for TaqMan low-density array gene expression analysis. From 93 selected genes related to cancer and cell cycle, we built a five-gene prognostic index after multiplicity correction. Using this index, we characterized two categories of patients with distinct overall survival (94% vs. 19% for good and poor overall survival, respectively; P = 0·007) and we successfully validated its strength on an independent cohort of 21 CMML patients with Affymetrix gene expression data. We found no specific patterns of association with traditional prognostic stratification parameters in the learning cohort. However, the poor survival group strongly correlated with high-risk treated patients and transformation to acute myeloid leukaemia. We report here a new multigene prognostic index for CMML, independent of the gene expression measurement method, which could be used as a powerful tool to predict clinical outcome and help physicians to evaluate criteria for treatments.
- Subjects :
- Male
Kaplan-Meier Estimate
Biology
Malignancy
Bioinformatics
Polymerase Chain Reaction
Pathogenesis
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Biomarkers, Tumor
medicine
Humans
RNA, Neoplasm
Aged
Oligonucleotide Array Sequence Analysis
030304 developmental biology
Aged, 80 and over
0303 health sciences
Gene Expression Profiling
Case-control study
Cancer
Leukemia, Myelomonocytic, Chronic
U937 Cells
Hematology
Middle Aged
Prognosis
medicine.disease
3. Good health
Gene expression profiling
Leukemia
Haematopoiesis
Treatment Outcome
Case-Control Studies
Multigene Family
030220 oncology & carcinogenesis
Cohort
Female
Follow-Up Studies
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 157
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi.dedup.....53ce0daadea285f32b4d9a214429fe10
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2012.09069.x