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EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis
- Source :
- Cell Reports, Vol. 18, No 1 (2017) pp. 213-224, Cell reports, vol. 18, no. 1, pp. 213-224
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4(+) T lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-OHC) via EBI2 in the MS murine model experimental autoimmune encephalomyelitis. However, the EBI2 expression profile in human lymphocytes in both healthy and MS donors is unknown. Here, we characterize EBI2 biology in human lymphocytes. We observed that EBI2 is functionally expressed on memory CD4(+) T cells and is enhanced under natalizumab treatment. These data suggest a significant role for EBI2 in human CD4(+) T cell migration, notably in patients with MS. Better knowledge of EBI2 involvement in autoimmunity may therefore lead to an improved understanding of the physiopathology of MS.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
0301 basic medicine
Multiple Sclerosis
ddc:616.07
CD11 Antigens/metabolism
CD4-Positive T-Lymphocytes/drug effects
CD4-Positive T-Lymphocytes/metabolism
Cell Movement/drug effects
Humans
Hydroxycholesterols/pharmacology
Immunologic Memory/drug effects
Multiple Sclerosis/immunology
Multiple Sclerosis/metabolism
Multiple Sclerosis/pathology
Natalizumab/pharmacology
Natalizumab/therapeutic use
Receptors, G-Protein-Coupled/metabolism
G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2)
lymphocyte trafficking
multiple sclerosis
natalizumab
oxysterols
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Receptors, G-Protein-Coupled
Autoimmunity
03 medical and health sciences
0302 clinical medicine
Natalizumab
Cell Movement
medicine
Receptor
Gene
ddc:616
CD11 Antigens
business.industry
Mechanism (biology)
Multiple sclerosis
Experimental autoimmune encephalomyelitis
medicine.disease
Hydroxycholesterols
Pathophysiology
3. Good health
030104 developmental biology
Immunology
business
Immunologic Memory
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Cell Reports
- Accession number :
- edsair.doi.dedup.....53c3350a89a4d6f8fd3ecf716210cd5a