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Obesity-related parameters and colorectal adenoma development
- Source :
- Journal of Gastroenterology. 52:1221-1229
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Obesity increases the risk of colorectal adenoma and colorectal cancer. However, the obesity-related parameters that are best for assessing the risk of colorectal adenoma development remain unclear. We analyzed the parameters that may best describe the association between obesity and colorectal adenoma development. In this retrospective cohort study, 3405 individuals underwent screening colonoscopy during routine health examinations. We measured body mass index; waist circumference; and metabolic parameters such as high-density lipoprotein-cholesterol, glucose, triglyceride, and systolic blood pressure. We analyzed the risk of developing colorectal adenoma, relative to obesity-related parameters, over a mean interval of 5.8 years from baseline colonoscopy. In a multivariate analysis, waist circumference was the only obesity-related marker associated with an increased risk of metachronous colorectal adenoma. Men with waist circumferences ≥85 cm and women with waist circumference ≥82 cm had a 31% increased risk of metachronous colorectal adenoma compared to those with smaller waist circumferences [odds ratio (OR) 1.31; 95% confidence interval (CI, 1.09–1.57)]. Other factors associated with metachronous colorectal adenoma were age (OR, 1.03; 95% CI 1.02–1.04), male sex (OR 1.49; 95% CI 1.17–1.88), alcohol consumption ≥3/week (OR 1.33; 95% CI 1.10–1.62), the number of adenoma at baseline (OR 1.21; 95% CI 1.10–1.33), and the presence of advanced adenoma at baseline (OR 1.60; 95% CI 1.24–2.06). Our findings suggest that central obesity, represented by waist circumference, is a significant predictor of metachronous colorectal adenoma, independent of body mass index and other metabolic variables.
- Subjects :
- Adenoma
Adult
Male
Oncology
medicine.medical_specialty
Waist
Colorectal cancer
Blood Pressure
Colorectal adenoma
Gastroenterology
Body Mass Index
Cohort Studies
03 medical and health sciences
Sex Factors
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Mass Screening
Obesity
Retrospective Studies
business.industry
Neoplasms, Second Primary
Colonoscopy
Odds ratio
Middle Aged
medicine.disease
Lipids
Colorectal surgery
Confidence interval
Obesity, Abdominal
030220 oncology & carcinogenesis
Multivariate Analysis
Female
030211 gastroenterology & hepatology
Waist Circumference
Colorectal Neoplasms
business
Body mass index
Subjects
Details
- ISSN :
- 14355922 and 09441174
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....53bb951cbb5904031af1145fb05379ba