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Obesity-related parameters and colorectal adenoma development

Authors :
Tae Jun Kim
Sung Noh Hong
Min-Ji Kim
Sin-Ho Jung
Dong Kyung Chang
Hee Jung Son
Jee Eun Kim
Yoon-Ho Choi
Poong-Lyul Rhee
Young-Ho Kim
Source :
Journal of Gastroenterology. 52:1221-1229
Publication Year :
2017
Publisher :
Springer Science and Business Media LLC, 2017.

Abstract

Obesity increases the risk of colorectal adenoma and colorectal cancer. However, the obesity-related parameters that are best for assessing the risk of colorectal adenoma development remain unclear. We analyzed the parameters that may best describe the association between obesity and colorectal adenoma development. In this retrospective cohort study, 3405 individuals underwent screening colonoscopy during routine health examinations. We measured body mass index; waist circumference; and metabolic parameters such as high-density lipoprotein-cholesterol, glucose, triglyceride, and systolic blood pressure. We analyzed the risk of developing colorectal adenoma, relative to obesity-related parameters, over a mean interval of 5.8 years from baseline colonoscopy. In a multivariate analysis, waist circumference was the only obesity-related marker associated with an increased risk of metachronous colorectal adenoma. Men with waist circumferences ≥85 cm and women with waist circumference ≥82 cm had a 31% increased risk of metachronous colorectal adenoma compared to those with smaller waist circumferences [odds ratio (OR) 1.31; 95% confidence interval (CI, 1.09–1.57)]. Other factors associated with metachronous colorectal adenoma were age (OR, 1.03; 95% CI 1.02–1.04), male sex (OR 1.49; 95% CI 1.17–1.88), alcohol consumption ≥3/week (OR 1.33; 95% CI 1.10–1.62), the number of adenoma at baseline (OR 1.21; 95% CI 1.10–1.33), and the presence of advanced adenoma at baseline (OR 1.60; 95% CI 1.24–2.06). Our findings suggest that central obesity, represented by waist circumference, is a significant predictor of metachronous colorectal adenoma, independent of body mass index and other metabolic variables.

Details

ISSN :
14355922 and 09441174
Volume :
52
Database :
OpenAIRE
Journal :
Journal of Gastroenterology
Accession number :
edsair.doi.dedup.....53bb951cbb5904031af1145fb05379ba