Back to Search
Start Over
Paclitaxel, carboplatin and gemcitabine combination as induction chemotherapy for stage IIIA N2 bulky non-small cell lung cancer
- Publication Year :
- 2005
-
Abstract
- Background: Induction chemotherapy followed by surgical resection or definitive radiotherapy for patients affected by stage IIIA N2 bulky non-small cell lung cancer (NSCLC) has been investigated in several trials. Patients and Methods: In this present study, 52 patients with stage IIIA N2 bulky NSCLC with cytologically or histologically confirmed mediastinal lymph node involvement received paclitaxel 175 mg/mq on day 1, carboplatin AUC 5 on day 1 and gemcitabine 1,000 mg/mq on day 1 and 8 every 3 weeks for three cycles as induction chemotherapy. Results: Objective response (4 complete remission and 36 partial remission) was achieved in 40/52 patients. No early or toxic deaths were observed. Twenty-two patients were surgically explored. Fifteen were excluded for resection for biopsy-proven residual tumour in mediastinal nodes. Complete surgical resection was performed in 15 patients with confirmed pathological downstaging. Pathological complete response was achieved in 4 patients. No surgery-related mortality or significant morbidity was reported. Adjuvant radiotherapy was delivered in 15 patients, and 30 patients received definitive radiotherapy. Conclusion: In the present study, the combination of paclitaxel, carboplatin and gemcitabine has been a safe and active regimen in poor-prognosis stage IIIA N2 bulky NSCLC.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Paclitaxel
medicine.drug_class
medicine.medical_treatment
Deoxycytidine
Antimetabolite
Disease-Free Survival
Drug Administration Schedule
Carboplatin
chemistry.chemical_compound
Carcinoma, Non-Small-Cell Lung
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Lung cancer
Aged
Neoplasm Staging
Chemotherapy
business.industry
Remission Induction
Induction chemotherapy
Lung cancer Paclitaxel Carboplatin, stage III Chemotherapy
General Medicine
Middle Aged
medicine.disease
Survival Analysis
Gemcitabine
respiratory tract diseases
Surgery
Radiation therapy
Treatment Outcome
chemistry
Chemotherapy, Adjuvant
Female
Radiotherapy, Adjuvant
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....53b73bcec2cfeed298d115050e2b736b