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Tachykinin-induced responses via neurokinin-1 and -3 receptors in hamster submandibular ganglion neurones

Authors :
Takashi Suzuki
T Soejima
Takayuki Endoh
Source :
Archives of Oral Biology. 44:455-463
Publication Year :
1999
Publisher :
Elsevier BV, 1999.

Abstract

Both substance P and neurokinin A are known as neurotransmitters of the submandibular ganglion cell. In this study, the effects of neurokinin (NK) receptor-subtype agonists on hamster submandibular ganglion cells were investigated using the whole-cell patch-clamp technique. Membrane currents evoked by a ramp pulse from +50 to −100 mV (−150 mV/1000 msec) were compared in both the absence and presence of NK receptor agonist. The NK-1 receptor agonist [Sar 9 , Met (O 2 ) 11 ]-substance P, the NK-2 receptor agonist [Ala 5 , β-Ala 8 ]-α-neurokinin fragment 4–10, and the NK-3 receptor agonist senktide were used. The three agonists dose-dependently increased the amplitude of the inward current with a reversal potential near 0 mV. Their rank order was NK-1=NK-3>NK-2. Even when the external solution was replaced with Cs + or N -methyl- d -glucamine + instead of Na + , the NK receptor agonists also increased the amplitude of the inward current. Thus, NK-1 and NK-3 receptors are apparently coupled with non-selective cation channels in submandibular ganglion cells.

Details

ISSN :
00039969
Volume :
44
Database :
OpenAIRE
Journal :
Archives of Oral Biology
Accession number :
edsair.doi.dedup.....53b49bc846e7955fc07555f9d13764ae
Full Text :
https://doi.org/10.1016/s0003-9969(99)00031-x