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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
- Publication Year :
- 2004
- Publisher :
- American Association for Cancer Research, 2004.
-
Abstract
- Transformed stem cells have been isolated from some human cancers. We report that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells. Similar, yet not identical, to their normal neural stem cell counterpart, these precursors emerge as unipotent (astroglial) in vivo and multipotent (neuronal-astroglial-oligodendroglial) in culture. More importantly, these cells can act as tumor-founding cells down to the clonal level and can establish tumors that closely resemble the main histologic, cytologic, and architectural features of the human disease, even when challenged through serial transplantation. Thus, cells possessing all of the characteristics expected from tumor neural stem cells seem to be involved in the growth and recurrence of adult human glioblastomas multiforme.
- Subjects :
- Nervous system
Adult
cancer stem cells
Cancer Research
Pathology
medicine.medical_specialty
Mice, SCID
Biology
Mice
Human disease
Cancer stem cell
In vivo
Neurosphere
Cell Line, Tumor
medicine
Animals
Humans
Neurons
Brain Neoplasms
Multipotent Stem Cells
medicine.disease
Neural stem cell
medicine.anatomical_structure
Cell Transformation, Neoplastic
Oncology
Cancer research
Neoplastic Stem Cells
Stem cell
Glioblastoma
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....53a977741e2de5b778cb20f1ddeb379c