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Nematodes as host resistance models for detection of immunotoxicity
- Source :
- Methods. 41:38-47
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Greater susceptibility to infection is a hallmark of compromised immune function in humans and animals, and is often considered the benchmark against which the predictive value of immune function tests are compared. The focus of this paper is resistance to infection with the parasitic nematode Trichinella spiralis as a model of host resistance. Topics include overviews of parasite biology, host immune responses that limit infection and methods used to evaluate the host response to infection. Detailed protocols are provided for adult and larval parasite counts, female parasite fecundity, parasite antigen-driven lymphocyte proliferation and antibody responses to infection.
- Subjects :
- Host (biology)
medicine.medical_treatment
Trichinella spiralis
Trichinellosis
Immunosuppression
Lymphocyte proliferation
Biology
Fecundity
biology.organism_classification
General Biochemistry, Genetics and Molecular Biology
Xenobiotics
Disease Models, Animal
Nematode
Immune system
Immune System
Immunology
medicine
Animals
Parasite hosting
Molecular Biology
Subjects
Details
- ISSN :
- 10462023
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Methods
- Accession number :
- edsair.doi.dedup.....539a9037f6bfb2bf537b7c5f2f14d6e4