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Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes
- Source :
- Endocrine
- Publication Year :
- 2021
- Publisher :
- Springer US, 2021.
-
Abstract
- Purpose To investigate and identify first-trimester fasting plasma glucose (FPG) is related to gestational diabetes mellitus (GDM) and other adverse pregnancy outcomes in Shenzhen population. Methods We used data of 48,444 pregnant women that had been retrospectively collected between 2017 and 2019. Logistic regression analysis was used to evaluated the associations between first-trimester FPG and GDM and adverse pregnancy outcomes, and used to construct a nomogram model for predicting the risk of GDM. The performance of the nomogram was evaluated by using ROC and calibration curves. Decision curve analysis (DCA) was used to determine the clinical usefulness of the first-trimester FPG by quantifying the net benefits at different threshold probabilities. Results The mean first-trimester FPG was 4.62 ± 0.42 mmol/L. A total of 6998 (14.4%) pregnancies developed GDM.489(1.01%) pregnancies developed polyhydramnios, the prevalence rates of gestational hypertensive disorder (GHD), cesarean section, primary cesarean section, preterm delivery before 37 weeks (PD) and dystocia was 1130 (2.33%), 20,426 (42.16%), 7237 (14.94%), 2386 (4.93%), and 1865 (3.85%), respectively. 4233 (8.74%) of the newborns were LGA, and the number of macrosomia was 2272 (4.69%), LBW was 1701 (3.51%) and 5084 (10.49%) newborns had admission to the ICU, which all showed significances between GDM and non-GDM groups (all P 1, all P P P Conclusions FPG in the first trimester was an independent risk factor for GDM which can be used as a screening test for identifying pregnancies at risk of GDM and adverse pregnancy outcomes.
- Subjects :
- Blood Glucose
medicine.medical_specialty
Polyhydramnios
Metabolic Diseases in Pregnancy
endocrine system diseases
GDM
Endocrinology, Diabetes and Metabolism
Population
Logistic regression
Fetal Macrosomia
Endocrinology
Pregnancy
Diabetes mellitus
Adverse Pregnancy Outcomes
Medicine
Humans
Risk factor
education
Retrospective Studies
The First Trimester FPG
education.field_of_study
business.industry
Obstetrics
Cesarean Section
Infant, Newborn
Pregnancy Outcome
nutritional and metabolic diseases
Fasting
Nomogram
Glucose Tolerance Test
medicine.disease
female genital diseases and pregnancy complications
Gestational diabetes
Diabetes, Gestational
Pregnancy Trimester, First
Gestation
Original Article
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 15590100 and 1355008X
- Volume :
- 75
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....538dd53522d5e492eca2e7cd71193a22