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No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study

Authors :
Michael Vieth
Susanne Moebus
Douglas A. Corley
Thomas Rösch
Jing Dong
Johannes Schumacher
René Thieme
Josef Weismüller
Horst Neuhaus
Prasad G. Iyer
Janusz Jankowski
Lothar Veits
Puya Gharahkhani
Harvey A. Risch
Jesper Lagergren
Wong-Ho Chow
Ines Gockel
Marilie D. Gammon
Thomas Schmidt
Yogesh K. Vashist
Christian Ell
Jessica Becker
Carlos Caldas
Anne C. Böhmer
Tania Noder
Jakob R. Izbicki
Mario Anders
Hauke Lang
Wilbert H.M. Peters
Arnulf H. Hölscher
Stuart MacGregor
Anna H. Wu
Weimin Ye
Michael Knapp
Marino Venerito
Markus M. Nöthen
Leslie Bernstein
Thomas L. Vaughan
Claire Palles
Lesley A. Anderson
Brian J. Reid
Paul D.P. Pharoah
Nicole Kreuser
Nicholas J. Shaheen
Ian Tomlinson
Dietmar Lorenz
Aaron P. Thrift
Rachel E. Neale
Claudia Schmidt
Sharon Love
Rupert Mayershofer
Lynn Onstad
Rebecca C. Fitzgerald
Brigitte Schumacher
Andrea May
Geoffrey Liu
David C. Whiteman
Katja Ott
Christian Gerges
Source :
Clin Gastroenterol Hepatol, Dong, J, Gharahkhani, P, Chow, W-H, Gammon, M D, Liu, G, Caldas, C, Wu, A H, Ye, W, Onstad, L, Anderson, L, Bernstein, L & Pharoah, P 2019, ' No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study ', Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association . https://doi.org/10.1016/j.cgh.2019.01.041, Clinical Gastroenterology and Hepatology, 17, 11, pp. 2227-2235.e1, Clinical Gastroenterology and Hepatology, 17, 2227-2235.e1
Publication Year :
2018

Abstract

Contains fulltext : 215282.pdf (Publisher’s version ) (Closed access) BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE). METHODS: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC. RESULTS: Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18). CONCLUSIONS: In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.

Details

ISSN :
15427714 and 15423565
Volume :
17
Issue :
11
Database :
OpenAIRE
Journal :
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Accession number :
edsair.doi.dedup.....537ce331eb368732e685ca66d907caf5