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No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study
- Source :
- Clin Gastroenterol Hepatol, Dong, J, Gharahkhani, P, Chow, W-H, Gammon, M D, Liu, G, Caldas, C, Wu, A H, Ye, W, Onstad, L, Anderson, L, Bernstein, L & Pharoah, P 2019, ' No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study ', Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association . https://doi.org/10.1016/j.cgh.2019.01.041, Clinical Gastroenterology and Hepatology, 17, 11, pp. 2227-2235.e1, Clinical Gastroenterology and Hepatology, 17, 2227-2235.e1
- Publication Year :
- 2018
-
Abstract
- Contains fulltext : 215282.pdf (Publisher’s version ) (Closed access) BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE). METHODS: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC. RESULTS: Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77-1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39-1.19; P = .18). CONCLUSIONS: In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.
- Subjects :
- Male
medicine.medical_specialty
Esophageal Neoplasms
Medizin
Single-nucleotide polymorphism
Adenocarcinoma
Gastroenterology
Polymorphism, Single Nucleotide
Risk Assessment
Article
Barrett Esophagus
Risk Factors
Internal medicine
Mendelian randomization
Epidemiology
medicine
Vitamin D and neurology
Biomarkers, Tumor
SNP
Humans
Vitamin D
Hepatology
business.industry
Odds ratio
DNA, Neoplasm
Esophageal cancer
Mendelian Randomization Analysis
medicine.disease
Europe
Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11]
Barrett's esophagus
North America
Female
Morbidity
business
Subjects
Details
- ISSN :
- 15427714 and 15423565
- Volume :
- 17
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
- Accession number :
- edsair.doi.dedup.....537ce331eb368732e685ca66d907caf5