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Organophosphate pesticide trichlorfon induced neurotoxic effects in freshwater silver catfish Rhamdia quelen via disruption of blood-brain barrier: Implications on oxidative status, cell viability and brain neurotransmitters
Organophosphate pesticide trichlorfon induced neurotoxic effects in freshwater silver catfish Rhamdia quelen via disruption of blood-brain barrier: Implications on oxidative status, cell viability and brain neurotransmitters
- Source :
- Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 218:8-13
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The aim of this study was to evaluate whether rupture on blood-brain barrier (BBB) can be a pathway for trichlorfon-induced neurotoxic effects, and to investigate its implications on oxidative status, cell viability and brain neurotransmitters in silver catfish (Rhamdia quelen). The BBB permeability was increased in fish exposed for 24 h to 22 mg/L of trichlorfon compared to the control group, as well as in those exposed to 11 and 22 mg/L of trichlorfon for 48 h. Compared to the control group, brain reactive oxygen species and lipid peroxide levels were higher when exposed to 22 mg/L of trichlorfon and 11 and 22 mg/L of trichlorfon after 24 h and 48 h, respectively, while the antioxidant capacity against peroxyl radical levels was lower. Exposure to 22 mg/L of trichlorfon for 24 h reduced brain cell viability compared to the control group, together with 11 and 22 mg/L of trichlorfon for 48 h. Also, brain AChE, Na+ and K+-ATPase activities were reduced in those fish exposed to trichlorfon compared to the control group. Thus, the rupture of BBB can be considered an important pathway involved in trichlorfon-induced neurotoxic effects, which contributes to brain oxidative damage and important changes on brain neurotransmitters.
- Subjects :
- Insecticides
Cell Survival
Physiology
Aché
Health, Toxicology and Mutagenesis
Oxidative phosphorylation
010501 environmental sciences
Pharmacology
Toxicology
Blood–brain barrier
01 natural sciences
Biochemistry
Gene Expression Regulation, Enzymologic
Fish Diseases
03 medical and health sciences
chemistry.chemical_compound
medicine
Animals
Viability assay
Trichlorfon
Catfishes
030304 developmental biology
0105 earth and related environmental sciences
chemistry.chemical_classification
0303 health sciences
Reactive oxygen species
Dose-Response Relationship, Drug
Lipid peroxide
Organophosphate
Neurotoxicity
Brain
Cell Biology
General Medicine
medicine.disease
language.human_language
Oxidative Stress
medicine.anatomical_structure
chemistry
Blood-Brain Barrier
Dichlorvos
Acetylcholinesterase
language
Nervous System Diseases
Sodium-Potassium-Exchanging ATPase
Subjects
Details
- ISSN :
- 15320456
- Volume :
- 218
- Database :
- OpenAIRE
- Journal :
- Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
- Accession number :
- edsair.doi.dedup.....5374ed8e26bac3d0174d44229468ac83
- Full Text :
- https://doi.org/10.1016/j.cbpc.2018.12.006