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Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome
- Source :
- Clinical Immunology. 126:31-37
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Oral lichen planus (OLP) and burning mouth syndrome (BMS) are chronic conditions affecting the oral mucosa characterized by pain and burning sensation. Saliva plays a significant role in the maintenance of physical and functional integrity of normal oral mucosa. Identification of potential "salivary biomarkers" for early diagnosis and/or monitoring of human diseases is being explored. We investigated the soluble forms of innate immune associated proteins CD14 and toll-like receptor-2 in unstimulated whole saliva (UWS) as potential biomarkers for OLP and BMS. Our results suggest that the levels of sCD14 and sTLR-2 in UWS were upregulated in OLP and BMS respectively. In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA. Interestingly, presence of co-existent oral candidiasis nullified these changes.
- Subjects :
- Male
Saliva
CD14
Freund's Adjuvant
Immunology
Lipopolysaccharide Receptors
Burning Mouth Syndrome
Biology
stomatognathic system
Candidiasis, Oral
Oral administration
medicine
Humans
Immunology and Allergy
RNA, Messenger
Oral mucosa
Toll-like receptor
Macrophages
Mouth Mucosa
Epithelial Cells
Macrophage Activation
Burning mouth syndrome
medicine.disease
Toll-Like Receptor 2
stomatognathic diseases
medicine.anatomical_structure
Oral microbiology
Cytokines
Female
Oral lichen planus
medicine.symptom
Biomarkers
Lichen Planus, Oral
Subjects
Details
- ISSN :
- 15216616
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Clinical Immunology
- Accession number :
- edsair.doi.dedup.....5373fb32c30bda9523d9fdff066ae269