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Biological Activities of the Essential Oil from Erigeron floribundus
- Source :
- Molecules, Molecules, Vol 21, Iss 8, p 1065 (2016), Molecules; Volume 21; Issue 8; Pages: 1065
- Publication Year :
- 2016
- Publisher :
- MDPI, 2016.
-
Abstract
- Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study, we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (inhibition zone diameter, IZD of 14 mm, minimum inhibitory concentration, MIC of 512 mu g/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 mu g/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 mu g/mL with the essential oil and 5.6 mu g/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 mu g/mL, and remarkable ferric reducing antioxidant power (tocopherol-equivalent antioxidant capacity, TEAC = 411.9 mu mol.TE/g).
- Subjects :
- life_sciences_other
Antioxidant
antioxidant
Erigeron
medicine.medical_treatment
tioxidant
caryophyllene oxide
Pharmaceutical Science
medicine.disease_cause
01 natural sciences
Antioxidants
Analytical Chemistry
law.invention
chemistry.chemical_compound
Mice
Anti-Infective Agents
law
Drug Discovery
Trypanosoma brucei
Traditional medicine
Antimicrobial
Farmakologi och toxikologi
Biochemistry
Chemistry (miscellaneous)
Staphylococcus aureus
Erigeron floribundus
Molecular Medicine
cytotoxicity
essential oil
antimicrobial
NadD
limonene
Cell Survival
Pharmacology and Toxicology
Microbial Sensitivity Tests
Biology
Article
lcsh:QD241-441
Minimum inhibitory concentration
Inhibitory Concentration 50
lcsh:Organic chemistry
Cell Line, Tumor
medicine
Oils, Volatile
Animals
Humans
Physical and Theoretical Chemistry
IC50
Essential oil
Limonene
Bacteria
010405 organic chemistry
Plant Extracts
Organic Chemistry
biology.organism_classification
Antineoplastic Agents, Phytogenic
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 21
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....53728f73be810e7d59960b7908ea7071